Arylation of Axially Chiral Phosphorothioate Salts by.
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The diastereroselective synthesis of proline-derived bicyclic 1,3,2oxazaphospholidines as synthons for stereoselective synthesis of phosphorothioate oligonucleotides has been reported and.
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A family of oligonucleotides and phosphorothioate oligonucleotide analogues was synthesized with a cholesteryl group tethered at the 3'-terminal internucleoside link. This modification, introduced to enhance interaction of the polyanions with cell membranes, significantly increases the antiviral activity of the oligomers, as judged by inhibition of syncytia formation and expression of viral.
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